ParticleScentryAI

ParticleSentryᴬᴵ is a patent-pending software platform that combines AI and particle imaging to support biologic drug development, scale-up, and manufacturing. By generating quantitative “fingerprints” of particle profiles, it detects protein aggregation under various stress conditions. This enables precise characterization and control of large molecule therapeutics throughout the entire product lifecycle.

Key Features

AI-driven particle fingerprinting captures subtle morphological and textural cues far beyond size/count.
Multi-modality compatibility: FIM, BMI, MFI and other image sources.
Outlier & anomaly detection with re-trainable models for new failure modes or stress conditions.
At-line/on-line process monitoring throughout scale-up and commercial manufacturing.
Rich statistical outputs—PDF fingerprint, confusion matrix, p-values and interactive visualisations.
Regulatory support for demonstrating a robust aggregate-control strategy.

Applications

Early formulation development
Process monitoring and quality control
Container closure evaluation
Shipping and stability studies
Outlier detection & root cause analysis
Retrospective image data analysis

Technical Highlights

Convolutional Neural Network extracts high-order image features; no manual descriptor engineering required.
2-D probability-density fingerprints built from thousands of particle images quantify normal vs. stressed states.
Goodness-of-fit hypothesis testing with p-value reporting flags process drift in real time.
Library of common bioprocess stressors (freeze-thaw, tangential-flow filtration, pump/filling, light, vibration) accelerates root-cause analysis.
GPU-accelerated analysis handles large datasets and delivers rapid batch or streaming results. (performance detail from product spec sheet)
Supersedes light-obscuration limits by resolving translucent protein particles and leveraging full image morphology.
Accepts lossless image formats (e.g., TIFF) and integrates with fluorescence, Raman and imaging-flow cytometry platforms for extended modality coverage.

Videos

ParticleSentryᴬᴵ – Curated Images
https://youtu.be/cF8fJTfHFWg

ParticleSentryᴬᴵ Compare FlowCam Video 2023
https://youtu.be/Sc_eWn2Efho

ParticleSentryᴬᴵ Create FlowCam Video 2023
https://youtu.be/2IXZCphsMTE

Combining AI and Flow Imaging Microscopy to Analyze and Monitor Biologics
https://youtu.be/A1JzO0-Sn2E

Contact Us

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